Another gem from Eleytherius.
Malignant Mesothelioma
Arises from serosal membrane lining, including pleural, cardial, peritoneal and scrotal cavities. In this case the pleural type is of interest.
- 90% are associated with asbestos exposure
- Clinical Features: chest pain, dyspnoea, recurrent pleural effusions
- Classification: Epithelioid, Sarcomatoid and Desmoplastic (e.g. mixed)
- Tumour with a predominantly papillary pattern
- Abundant and acidophilic cytoplasm.
- Pattern of chromatin (clumped, hyperchromatic)
- large amounts of keratin proteins
- Diffusely spread over lung surface (i.e. pleura)
- Thick layer of gelatinous, grayish-pink tissue
Solitary Fibrous Tumour or Pleural Fibroma
- Essentially benign Mesothelioma
- No relationship to asbestos exposure
- Soft tissue tumour
- Resection is curative
Solitary fibrous tumor of pleura by Pulmonary Pathology
This tumor presented as a pedunculated intrapleural mass arising from the visceral pleura. Although most of these tumors are benign, microscopic features such as mitotic activity, necrosis, cellular atypia and size greater than 10 cm. may correlate with malignant behavior.
Secondary Tumours
Metastases can also spread to the lung pleural (e.g. lung, breast, ovary).
Further Resources
References
Videos are thanks to WashingtonDeceit. Material is sourced from my notes from pathology tutorials at UQ, and Robbin's Pathologic Basis of Disease. References for images are underneath the image.
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